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The mesolimbic and mesocortical dopaminergic structures are believed to play energetic position in motivation. Cocaine is thought to boom the dopaminergic activity inside the mesolimbic areas of mind by inhibiting dopamine re-uptake in the ventral tegmental region and nucleus accumbens. Three. Serotonin five-Hydroxytryptamine, five-HT Serotonin was remoted from blood serum as a substance answerable for causing muscle contraction.