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Precursors of Neurotransmitters Different precursors are wished for the synthesis of different neurotransmitters. For instance, L-DOPA is the precursor for dopamine synthesis that crosses the blood brain barrier and is used inside the remedy of Parkinson's sickness. In case of depressed sufferers the activity of norepinephrine is diminished, so the precursors for this neurotransmitter are administered externally. The precursors for this neurotransmitter are L-phenylalanine and L-tyrosine.